The microbial metagenome and bone tissue composition in mice with microbiome-induced reductions in bone strength.

ABSTRACT: The genetic components of microbial species that inhabit the body are known collectively as the microbiome. Modifications to the microbiome have been implicated in disease processes throughout the body and have recently been shown to influence bone. Prior work has associated changes in the microbial taxonomy (phyla, class, species, etc.) in the gut with bone phenotypes but has provided limited information regarding mechanisms. With the goal of achieving a more mechanistic understanding of the effects of the microbiome on bone, we perform a metagenomic analysis of the gut microbiome that provides information on the functional capacity of the microbes (all microbial genes present) rather than only characterizing the microbial taxa. Male C57Bl/6 mice were subjected to disruption of the gut mi

SUBMITTER: Guss JD 

PROVIDER: S-EPMC6708759 | biostudies-literature | 2019 Oct

REPOSITORIES: biostudies-literature