Dataset Information

Incidence and risk of fatigue in cancer patients treated with MET inhibitors: A systematic review and meta-analysis.

ABSTRACT:

Background

The N-methyl-N'-nitroso-guanidine human osteosarcoma transforming gene (MET) inhibitors show a surprising survival benefit in the treatment of numerous tumors especially in MET-high tumor. Besides their impressive efficacy, fatigue reduced by MET inhibitors is still the safety issue during treatment. Thus, an understanding of this risk in the context of expanding MET-inhibitors use is an important cost and patient safety issue.

Methods

We searched PubMed, Embase, and the Cochrane Library databases for relevant studies up to October 2017. Eligibility criteria included phase II/III trials of MET inhibitors that reported adequate safety profiles of fatigue. The principal summary measures were incidence and relative risk (RR) of all-grade (grade 1-4) and high-grade (grade 3-4) fatigue, respectively. Random-effects model was applied to consider within-study and between-study variation.

Results

A total of 5028 patients from 17 clinical trials were identified. The results revealed that the incidences of MET inhibitors-associated all-grade and high-grade fatigue were 41.9% and 9.6%, respectively. The RR of high-grade fatigue was (RR?=?1.37; 95% confidence interval, 1.14-1.66; P?=?.0009), whereas the RR of all-grade fatigue was (RR?=?1.02; 95% confidence interval, 0.91-1.15; P?=?.71).

Conclusion

Our meta-analysis has demonstrated that MET inhibitors-based treatment is associated with an increased risk of high-grade fatigue compared with control.

SUBMITTER: Tong H

PROVIDER: S-EPMC6709275 | biostudies-literature | 2019 May

REPOSITORIES: biostudies-literature

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Publications

Incidence and risk of fatigue in cancer patients treated with MET inhibitors: A systematic review and meta-analysis.

Tong Hongxuan H Zhu Yutian Y Liu Yihua Y

Medicine 20190501 22

<h4>Background</h4>The N-methyl-N'-nitroso-guanidine human osteosarcoma transforming gene (MET) inhibitors show a surprising survival benefit in the treatment of numerous tumors especially in MET-high tumor. Besides their impressive efficacy, fatigue reduced by MET inhibitors is still the safety issue during treatment. Thus, an understanding of this risk in the context of expanding MET-inhibitors use is an important cost and patient safety issue.<h4>Methods</h4>We searched PubMed, Embase, and th ...[more]

PMID: 31145273

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Dataset Information

Incidence and risk of fatigue in cancer patients treated with MET inhibitors: A systematic review and meta-analysis.

Background

Methods

Results

Conclusion

Publications

Incidence and risk of fatigue in cancer patients treated with MET inhibitors: A systematic review and meta-analysis.

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