Evolution of Carbapenem-Resistant Serotype K1 Hypervirulent Klebsiella pneumoniae by Acquisition of bla VIM-1-Bearing Plasmid.
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ABSTRACT:
SUBMITTER: Dong N
PROVIDER: S-EPMC6709456 | biostudies-literature | 2019 Sep
REPOSITORIES: biostudies-literature
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Evolution of Carbapenem-Resistant Serotype K1 Hypervirulent Klebsiella pneumoniae by Acquisition of <i>bla</i><sub>VIM-1</sub>-Bearing Plasmid.
Dong Ning N Sun Qiaoling Q Huang Yonglu Y Shu Lingbin L Ye Lianwei L Zhang Rong R Chen Sheng S
Antimicrobial agents and chemotherapy 20190823 9
We report the identification of a carbapenem-resistant, hypervirulent <i>Klebsiella pneumoniae</i> (hvKp) strain which produced the carbapenemase VIM-1. Genomic analysis showed that the strain belonged to sequence type ST23 and serotype K1, a major hvKp clone, and harbored three resistance-encoding plasmids. Among them, a <i>bla</i><sub>VIM-1</sub>-bearing plasmid was found to possess a mosaic structure presumably generated by multiple gene mobilization events. This finding indicates that hvKp a ...[more]
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