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Tn6674 Is a Novel Enterococcal optrA-Carrying Multiresistance Transposon of the Tn554 Family.


ABSTRACT: The novel 12,932-bp nonconjugative multiresistance transposon Tn6674 was identified in the chromosomal DNA of a porcine Enterococcus faecalis strain. Tn6674 belongs to the Tn554 family of transposons. It shares the same arrangement of the transposase genes tnpA, tnpB, and tnpC with Tn554 However, in addition to the Tn554-associated resistance genes spc and erm(A), Tn6674 harbored the resistance genes fexA and optrA Circular forms of Tn6674 were detected and suggest the functional activity of this transposon.

SUBMITTER: Li D 

PROVIDER: S-EPMC6709469 | biostudies-literature | 2019 Sep

REPOSITORIES: biostudies-literature

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Tn<i>6674</i> Is a Novel Enterococcal <i>optrA</i>-Carrying Multiresistance Transposon of the Tn<i>554</i> Family.

Li Dexi D   Li Xing-Yun XY   Schwarz Stefan S   Yang Mengyan M   Zhang Su-Mei SM   Hao Wenbo W   Du Xiang-Dang XD  

Antimicrobial agents and chemotherapy 20190823 9


The novel 12,932-bp nonconjugative multiresistance transposon Tn<i>6674</i> was identified in the chromosomal DNA of a porcine <i>Enterococcus faecalis</i> strain. Tn<i>6674</i> belongs to the Tn<i>554</i> family of transposons. It shares the same arrangement of the transposase genes <i>tnpA</i>, <i>tnpB,</i> and <i>tnpC</i> with Tn<i>554</i> However, in addition to the Tn<i>554</i>-associated resistance genes <i>spc</i> and <i>erm</i>(A), Tn<i>6674</i> harbored the resistance genes <i>fexA</i>  ...[more]

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