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Repurposing Quinacrine against Ebola Virus Infection In Vivo.

ABSTRACT: Quinacrine hydrochloride is a small-molecule, orally bioavailable drug that has been used clinically as an antimalarial and for many other applications. A machine learning model trained on Ebola virus (EBOV) screening data identified quinacrine as a potent (nanomolar) in vitro inhibitor. In the current study, quinacrine 25?mg/kg was shown to protect 70% of mice (statistically significant) from a lethal challenge with mouse-adapted EBOV with once-daily intraperitoneal dosing for 8?days.

SUBMITTER: Lane TR

PROVIDER: S-EPMC6709481 | biostudies-literature | 2019 Sep

REPOSITORIES: biostudies-literature

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Repurposing Quinacrine against Ebola Virus Infection In Vivo.

Lane Thomas R TR Comer Jason E JE Freiberg Alexander N AN Madrid Peter B PB Ekins Sean S

Antimicrobial agents and chemotherapy 20190823 9

Quinacrine hydrochloride is a small-molecule, orally bioavailable drug that has been used clinically as an antimalarial and for many other applications. A machine learning model trained on Ebola virus (EBOV) screening data identified quinacrine as a potent (nanomolar) in vitro inhibitor. In the current study, quinacrine 25 mg/kg was shown to protect 70% of mice (statistically significant) from a lethal challenge with mouse-adapted EBOV with once-daily intraperitoneal dosing for 8 days. ...[more]

PMID: 31307979

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