Nucleoside Analogs with Antiviral Activity against Yellow Fever Virus.
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ABSTRACT:
SUBMITTER: Zandi K
PROVIDER: S-EPMC6709485 | biostudies-literature | 2019 Sep
REPOSITORIES: biostudies-literature
Publications
Nucleoside Analogs with Antiviral Activity against Yellow Fever Virus.
Zandi Keivan K Amblard Franck F Amichai Sarah S Bassit Leda L Tao Sijia S Jiang Yong Y Zhou Longhu L Ollinger Russell Olivia O Mengshetti Seema S Schinazi Raymond F RF
Antimicrobial agents and chemotherapy 20190823 9
Yellow fever virus (YFV) is a human <i>Flavivirus</i> reemerging in parts of the world. While a vaccine is available, large outbreaks have recently occurred in Brazil and certain African countries. Development of an effective antiviral against YFV is crucial, as there is no available effective drug against YFV. We have identified several novel nucleoside analogs with potent antiviral activity against YFV with 50% effective concentration (EC<sub>50</sub>) values between 0.25 and 1 μM with selecti ...[more]
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