Ontology highlight
ABSTRACT:
SUBMITTER: Iida N
PROVIDER: S-EPMC6709532 | biostudies-literature | 2013 Nov
REPOSITORIES: biostudies-literature
Iida Noriho N Dzutsev Amiran A Stewart C Andrew CA Smith Loretta L Bouladoux Nicolas N Weingarten Rebecca A RA Molina Daniel A DA Salcedo Rosalba R Back Timothy T Cramer Sarah S Dai Ren-Ming RM Kiu Hiu H Cardone Marco M Naik Shruti S Patri Anil K AK Wang Ena E Marincola Francesco M FM Frank Karen M KM Belkaid Yasmine Y Trinchieri Giorgio G Goldszmid Romina S RS
Science (New York, N.Y.) 20131101 6161
The gut microbiota influences both local and systemic inflammation. Inflammation contributes to development, progression, and treatment of cancer, but it remains unclear whether commensal bacteria affect inflammation in the sterile tumor microenvironment. Here, we show that disruption of the microbiota impairs the response of subcutaneous tumors to CpG-oligonucleotide immunotherapy and platinum chemotherapy. In antibiotics-treated or germ-free mice, tumor-infiltrating myeloid-derived cells respo ...[more]