Ontology highlight
ABSTRACT:
SUBMITTER: Jaeger K
PROVIDER: S-EPMC6709783 | biostudies-literature | 2019 Aug
REPOSITORIES: biostudies-literature
Jaeger Kathrin K Bruenle Steffen S Weinert Tobias T Guba Wolfgang W Muehle Jonas J Miyazaki Takuya T Weber Martin M Furrer Antonia A Haenggi Noemi N Tetaz Tim T Huang Chia-Ying CY Mattle Daniel D Vonach Jean-Marie JM Gast Alain A Kuglstatter Andreas A Rudolph Markus G MG Nogly Przemyslaw P Benz Joerg J Dawson Roger J P RJP Standfuss Joerg J
Cell 20190801 5
The CC chemokine receptor 7 (CCR7) balances immunity and tolerance by homeostatic trafficking of immune cells. In cancer, CCR7-mediated trafficking leads to lymph node metastasis, suggesting the receptor as a promising therapeutic target. Here, we present the crystal structure of human CCR7 fused to the protein Sialidase NanA by using data up to 2.1 Å resolution. The structure shows the ligand Cmp2105 bound to an intracellular allosteric binding pocket. A sulfonamide group, characteristic for va ...[more]