Unknown

Dataset Information

0

Expansion of Luminal Progenitor Cells in the Aging Mouse and Human Prostate.

ABSTRACT: Aging is associated with loss of tissue mass and a decline in adult stem cell function in many tissues. In contrast, aging in the prostate is associated with growth-related diseases including benign prostatic hyperplasia (BPH). Surprisingly, the effects of aging on prostate epithelial cells have not been established. Here we find that organoid-forming progenitor activity of mouse prostate basal and luminal cells is maintained with age. This is caused by an age-related expansion of progenitor-like luminal cells that share features with human prostate luminal progenitor cells. The increase in luminal progenitor cells may contribute to greater risk for growth-related disease in the aging prostate. Importantly, we demonstrate expansion of human luminal progenitor cells in BPH. In summary, we define a Trop2+ luminal progenitor subset and identify an age-related shift in the luminal compartment of the mouse and human prostate epithelium.

SUBMITTER: Crowell PD 

PROVIDER: S-EPMC6710009 | biostudies-literature | 2019 Aug

REPOSITORIES: biostudies-literature

Json Xml
altmetric image

Publications

Aging is associated with loss of tissue mass and a decline in adult stem cell function in many tissues. In contrast, aging in the prostate is associated with growth-related diseases including benign prostatic hyperplasia (BPH). Surprisingly, the effects of aging on prostate epithelial cells have not been established. Here we find that organoid-forming progenitor activity of mouse prostate basal and luminal cells is maintained with age. This is caused by an age-related expansion of progenitor-lik  ...[more]

Similar Datasets

Unknown Identification of multipotent luminal progenitor cells in human prostate organoid cultures.
| S-EPMC4772677 | biostudies-literature
Unknown Defined conditions for the isolation and expansion of basal prostate progenitor cells of mouse and human origin.
| S-EPMC4375832 | biostudies-literature
Unknown Identification of Different Classes of Luminal Progenitor Cells within Prostate Tumors.
| S-EPMC4840850 | biostudies-literature
Unknown Accumulating progenitor cells in the luminal epithelial cell layer are candidate tumor initiating cells in a Pten knockout mouse prostate cancer model.
| S-EPMC2680948 | biostudies-literature
Unknown Transcriptomic Signature and Growth Factor Regulation of Castration-Tolerant Prostate Luminal Progenitor Cells.
| S-EPMC9367377 | biostudies-literature
Unknown Formaldehyde induces micronuclei in mouse erythropoietic cells and suppresses the expansion of human erythroid progenitor cells.
| S-EPMC3891867 | biostudies-literature
Unknown Low CD38 Identifies Progenitor-like Inflammation-Associated Luminal Cells that Can Initiate Human Prostate Cancer and Predict Poor Outcome.
| S-EPMC5367888 | biostudies-literature
Unknown Bmi1 marks distinct castration-resistant luminal progenitor cells competent for prostate regeneration and tumour initiation.
| S-EPMC5059479 | biostudies-literature
Unknown eIF4E threshold levels differ in governing normal and neoplastic expansion of mammary stem and luminal progenitor cells.
| S-EPMC4333007 | biostudies-literature
Unknown Induced p53 loss in mouse luminal cells causes clonal expansion and development of mammary tumours.
| S-EPMC5316831 | biostudies-literature