Depressive symptoms and immune transcriptional profiles in late adolescents.
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ABSTRACT: BACKGROUND:Rates of depression increase and peak during late adolescence and alterations in immune processes are thought to be both a risk factor and outcome of depression. However, few studies have examined depression-immune dynamics among adolescents. Using a functional genomics approach, the current study examined whether depressive symptoms were associated with activation of a gene expression profile, characterized by upregulated expression of pro-inflammatory-related genes and downregulated expression of antiviral-related genes in a sample of older adolescents (Mage?=?18.37, SD?=?0.51). METHOD:Participants (n?=?87) reported on their depressive symptoms during the past week using the CES-D, and provided blood samples for genome-wide transcriptional profiling of mRNA. RESULTS:Adolescents with clinically-significant levels of depressive symptoms (CES-D???16) exhibited upregulated expression of inflammation-related genes and downregulated expression of antiviral-related genes compared to their peers with lower levels of depressive symptoms (CES-D?
SUBMITTER: Chiang JJ
PROVIDER: S-EPMC6710012 | biostudies-literature | 2019 Aug
REPOSITORIES: biostudies-literature
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