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Immediate versus delayed control demands elicit distinct mechanisms for instantiating proactive control.

ABSTRACT: Cognitive control is critical for dynamically guiding goal-directed behavior, particularly when applying preparatory, or proactive, control processes. However, it is unknown how proactive control is modulated by timing demands. This study investigated how timing demands may instantiate distinct neural processes and contribute to the use of different types of proactive control. In two experiments, healthy young adults performed the AX-Continuous Performance Task (AX-CPT) or Dot Pattern Expectancy (DPX) task. The delay between informative cue and test probe was manipulated by block to be short (1s) or long (~3s). We hypothesized that short cue-probe delays would rely more on a rapid goal updating process (akin to task-switching), whereas long cue-probe delays would utilize more of an active maintenance process (akin to working memory). Short delay lengths were associated with specific impairments in rare probe accuracy. EEG responses to control-demanding cues revealed delay-specific neural signatures, which replicated across studies. In the short delay condition, EEG activities associated with task-switching were specifically enhanced, including increased early anterior positivity ERP amplitude (accompanying greater mid-frontal theta power) and a larger late differential switch positivity. In the long delay condition, we observed study-specific sustained increases in ERP amplitude following control-demanding cues, which may be suggestive of active maintenance. Collectively, these findings suggest that timing demands may instantiate distinct proactive control processes. These findings suggest a reevaluation of AX-CPT and DPX as pure assessments of working memory and highlight the need to understand how presumably benign task parameters, such as cue-probe delay length, significantly alter cognitive control.

SUBMITTER: Janowich JR

PROVIDER: S-EPMC6710156 | biostudies-literature | 2019 Aug

REPOSITORIES: biostudies-literature

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Immediate versus delayed control demands elicit distinct mechanisms for instantiating proactive control.

Janowich Jacqueline R JR Cavanagh James F JF

Cognitive, affective & behavioral neuroscience 20190801 4

Cognitive control is critical for dynamically guiding goal-directed behavior, particularly when applying preparatory, or proactive, control processes. However, it is unknown how proactive control is modulated by timing demands. This study investigated how timing demands may instantiate distinct neural processes and contribute to the use of different types of proactive control. In two experiments, healthy young adults performed the AX-Continuous Performance Task (AX-CPT) or Dot Pattern Expectancy ...[more]

PMID: 30607833

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Project description:BackgroundImmediately sequential bilateral cataract surgery (ISBCS), the cataract surgery that is performed in both eyes simultaneously, is gaining popularity worldwide compared to the traditional treatment paradigm: delayed sequential bilateral cataract surgery (DSBCS), the surgery that is performed in each eye on a different day as a completely separate operation. ISBCS provides advantages to patients and patients' families in the form of fewer hospital visits. Additionally, patients enjoy rapid rehabilitation, lack of anisometropia - potentially reducing accidents and falls, and avoid suboptimal visual function in daily life. The hospital may benefit due to lower cost.ObjectiveTo perform a systematic review and meta-analysis to evaluate ISBCS and DSBCS.Data sourcesDatabases including MEDLINE, EMBASE, BIOSIS, CINAHL, Health Economic Evaluations Database (HEED), ISI Web of Science (Thomson-Reuters) and the Cochrane Library were searched.ParticipantsNot applicable.MethodsLiterature was systematically reviewed using EPPI-Reviewer 4 gateway. Meta-analysis was conducted using STATA v. 13.0. Standardized mean difference (SMD) and 95% confidence intervals (CI) were calculated and heterogeneity was assessed using I2 statistics. Fixed-effect and random-effect models were computed based on heterogeneity. Meta-analysis was done by instrument used to calculate utility score.ResultsIn total, 9,133 records were retrieved from multiple databases and an additional 128 records were identified through grey literature search. Eleven articles with 3,657 subjects were included for analysis. Our meta-analysis results indicated significant improvement in post-operative utility score using TTO, EQ5D, HUI3, VF-7, and VF-14 and a non-significant improvement using Catquest questionnaire for both surgeries. For ISBCS versus DSBCS, utility-specific fixed-effect model provided an overall SMD of the utility score using the TTO method as 0.12 (95% CI: -0.15, 0.40), EQ5D as 0.14 (95% CI: -0.14, 0.41), HUI3 as 0.12 (95% CI: -0.15, 0.40), VF-7 as -0.02 (95% CI: -0.15, 0.10), and Catquest Questionnaire as 1.45 (95% CI: -0.88, 2.01). The results for utility score, which were measured using various instruments, indicated non-significant improvement in the utility due to DSBCS compared to ISBCS. However, a significant improvement in post-operative utility score was seen using Catquest questionnaire for ISBCS compared to DSBCS. The included studies using VF-14 instrument were highly heterogeneous (I2 = 97.1%). Results provided SMD of -0.25 (95% CI:-1.06, 0.57) using VF-14 indicating non-significant improvement in the utility due to DSBCS compared to ISBCS surgery. Best corrected visual acuity (BCVA) significantly improved after both surgeries (overall SMD of BCVA due to ISBCS was -1.79 (95% CI: -2.45, -1.14) and due to DSBCS was -1.53 (95% CI: -2.25, -0.81)). A non-significant improvement was seen in BCVA due to ISBCS when compared to DSBCS (SMD = -0.18; 95% CI: -0.37, 0.01).ConclusionBoth surgeries, ISBCS and DSBCS significantly improve patients' quality of life and visual acuity. Further, ISBCS may deliver certain additional benefits at the individual and societal levels as well.

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Immediate versus delayed control demands elicit distinct mechanisms for instantiating proactive control.

Publications

Immediate versus delayed control demands elicit distinct mechanisms for instantiating proactive control.

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