Ontology highlight
ABSTRACT:
SUBMITTER: Wu D
PROVIDER: S-EPMC6710248 | biostudies-literature | 2019 Aug
REPOSITORIES: biostudies-literature
Wu Di D Yan Junhong J Shen Xia X Sun Yu Y Thulin Måns M Cai Yanling Y Wik Lotta L Shen Qiujin Q Oelrich Johan J Qian Xiaoyan X Dubois K Louise KL Ronquist K Göran KG Nilsson Mats M Landegren Ulf U Kamali-Moghaddam Masood M
Nature communications 20190826 1
Exosomes have been implicated in numerous biological processes, and they may serve as important disease markers. Surface proteins on exosomes carry information about their tissues of origin. Because of the heterogeneity of exosomes it is desirable to investigate them individually, but this has so far remained impractical. Here, we demonstrate a proximity-dependent barcoding assay to profile surface proteins of individual exosomes using antibody-DNA conjugates and next-generation sequencing. We f ...[more]