Ontology highlight
ABSTRACT:
SUBMITTER: Libis V
PROVIDER: S-EPMC6710260 | biostudies-literature | 2019 Aug
REPOSITORIES: biostudies-literature
Libis Vincent V Antonovsky Niv N Zhang Mengyin M Shang Zhuo Z Montiel Daniel D Maniko Jeffrey J Ternei Melinda A MA Calle Paula Y PY Lemetre Christophe C Owen Jeremy G JG Brady Sean F SF
Nature communications 20190826 1
Sequencing of DNA extracted from environmental samples can provide key insights into the biosynthetic potential of uncultured bacteria. However, the high complexity of soil metagenomes, which can contain thousands of bacterial species per gram of soil, imposes significant challenges to explore secondary metabolites potentially produced by rare members of the soil microbiome. Here, we develop a targeted sequencing workflow termed CONKAT-seq (co-occurrence network analysis of targeted sequences) t ...[more]