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An epigenome-wide analysis of cord blood DNA methylation reveals sex-specific effect of exposure to bisphenol A.


ABSTRACT: Exposure to bisphenol A (BPA) in utero is associated with adverse health outcome of the offspring. Differential DNA methylation at specific CpG sites may link BPA exposure to health impacts. We examined the association of prenatal BPA exposure with genome-wide DNA methylation changes in cord blood in 277 mother-child pairs in the Hokkaido Study on Environment and Children's Health, using the Illumina HumanMethylation 450 BeadChip. We observed that a large portion of BPA-associated differentially methylated CpGs with p-value?

SUBMITTER: Miura R 

PROVIDER: S-EPMC6710292 | biostudies-literature | 2019 Aug

REPOSITORIES: biostudies-literature

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An epigenome-wide analysis of cord blood DNA methylation reveals sex-specific effect of exposure to bisphenol A.

Miura Ryu R   Araki Atsuko A   Minatoya Machiko M   Miyake Kunio K   Chen Mei-Lien ML   Kobayashi Sumitaka S   Miyashita Chihiro C   Yamamoto Jun J   Matsumura Toru T   Ishizuka Mayumi M   Kubota Takeo T   Kishi Reiko R  

Scientific reports 20190826 1


Exposure to bisphenol A (BPA) in utero is associated with adverse health outcome of the offspring. Differential DNA methylation at specific CpG sites may link BPA exposure to health impacts. We examined the association of prenatal BPA exposure with genome-wide DNA methylation changes in cord blood in 277 mother-child pairs in the Hokkaido Study on Environment and Children's Health, using the Illumina HumanMethylation 450 BeadChip. We observed that a large portion of BPA-associated differentially  ...[more]

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