Epigenetic inhibitor zebularine activates ear pinna wound closure in the mouse.

ABSTRACT: BACKGROUND:Most studies on regenerative medicine focus on cell-based therapies and transplantations. Small-molecule therapeutics, though proved effective in different medical conditions, have not been extensively investigated in regenerative research. It is known that healing potential decreases with development and developmental changes are driven by epigenetic mechanisms, which suggests epigenetic repression of regenerative capacity. METHODS:We applied zebularine, a nucleoside inhibitor of DNA methyltransferases, to stimulate the regenerative response in a model of ear pinna injury in mice. FINDINGS:We observed the regeneration of complex tissue that was manifested as improved ear hole repair in mice that received intraperitoneal injections of zebularine. Six weeks after injury, the mean hole area decreased by 83.2?±?9.4% in zebularine-treated and by 43.6?±?15.4% in control mice (p?

SUBMITTER: Sass P 

PROVIDER: S-EPMC6710911 | biostudies-literature | 2019 Aug

REPOSITORIES: biostudies-literature