Quality of Anticoagulation With Vitamin K Antagonists.

ABSTRACT:

Background

Vitamin K antagonists (VKA) have a narrow therapeutic range, and literature analysis reveals poor quality of anticoagulation control. We sought to assess the prevalence of poor anticoagulant control in patients under VKA treatment in the prevention of stroke for atrial fibrillation (AF).

Hypothesis

Control of anticoagulation with VKA is inadequate in a high percentage of patients with AF.

Methods

Patients with AF under VKA treatment were prospectively recruited in this observational registry. The sample comprised 948 patients. The estimated time spent in the therapeutic range (TTR) was calculated, and variables related with a TTR >65% were analyzed.

Results

Mean age was 73.8 ± 9.4 years, and 42.5% of the patients were women. Mean TTR was 63.77% ± 23.

SUBMITTER: Bertomeu-Gonzalez V 

PROVIDER: S-EPMC6711074 | biostudies-literature | 2015 Jun

REPOSITORIES: biostudies-literature