Ontology highlight
ABSTRACT:
SUBMITTER: Nagdas S
PROVIDER: S-EPMC6711191 | biostudies-literature | 2019 Aug
REPOSITORIES: biostudies-literature
Nagdas Sarbajeet S Kashatus Jennifer A JA Nascimento Aldo A Hussain Syed S SS Trainor Riley E RE Pollock Sarah R SR Adair Sara J SJ Michaels Alex D AD Sesaki Hiromi H Stelow Edward B EB Bauer Todd W TW Kashatus David F DF
Cell reports 20190801 7
Mitochondria undergo fission and fusion to maintain homeostasis, and tumors exhibit the dysregulation of mitochondrial dynamics. We recently demonstrated that ectopic HRas<sup>G12V</sup> promotes mitochondrial fragmentation and tumor growth through Erk phosphorylation of the mitochondrial fission GTPase Dynamin-related protein 1 (Drp1). However, the role of Drp1 in the setting of endogenous oncogenic KRas remains unknown. Here, we show that Drp1 is required for KRas-driven anchorage-independent ...[more]