Ontology highlight
ABSTRACT:
SUBMITTER: Siegenthaler D
PROVIDER: S-EPMC6711512 | biostudies-literature | 2019 Aug
REPOSITORIES: biostudies-literature
Siegenthaler Dominique D Escribano Benjamin B Bräuler Vanessa V Pielage Jan J
PLoS biology 20190827 8
Adaptive decision-making depends on the formation of novel memories. In Drosophila, the mushroom body (MB) is the site of associative olfactory long-term memory (LTM) storage. However, due to the sparse and stochastic representation of olfactory information in Kenyon cells (KCs), genetic access to individual LTMs remains elusive. Here, we develop a cAMP response element (CRE)-activity-dependent memory engram label (CAMEL) tool that genetically tags KCs responding to the conditioned stimulus (CS) ...[more]