Ontology highlight
ABSTRACT:
SUBMITTER: Shemorry A
PROVIDER: S-EPMC6711704 | biostudies-literature | 2019 Aug
REPOSITORIES: biostudies-literature
Shemorry Anna A Harnoss Jonathan M JM Harnoss Jonathan M JM Guttman Ofer O Marsters Scot A SA Kőműves László G LG Lawrence David A DA Ashkenazi Avi A
eLife 20190827
Upon detecting endoplasmic reticulum (ER) stress, the unfolded protein response (UPR) orchestrates adaptive cellular changes to reestablish homeostasis. If stress resolution fails, the UPR commits the cell to apoptotic death. Here we show that in hematopoietic cells, including multiple myeloma (MM), lymphoma, and leukemia cell lines, ER stress leads to caspase-mediated cleavage of the key UPR sensor IRE1 within its cytoplasmic linker region, generating a stable IRE1 fragment comprising the ER-lu ...[more]