Ontology highlight
ABSTRACT:
SUBMITTER: Lari A
PROVIDER: S-EPMC6711706 | biostudies-literature | 2019 Aug
REPOSITORIES: biostudies-literature
Lari Azra A Arul Nambi Rajan Arvind A Sandhu Rima R Reiter Taylor T Montpetit Rachel R Young Barry P BP Loewen Chris Jr CJ Montpetit Ben B
eLife 20190827
Dbp5 is an essential DEAD-box protein that mediates nuclear mRNP export. Dbp5 also shuttles between nuclear and cytoplasmic compartments with reported roles in transcription, ribosomal subunit export, and translation; however, the mechanism(s) by which nucleocytoplasmic transport occurs and how Dbp5 specifically contributes to each of these processes remains unclear. Towards understanding the functions and transport of Dbp5 in <i>Saccharomyces cerevisiae</i>, alanine scanning mutagenesis was use ...[more]