Transcription factor c-Myb inhibits breast cancer lung metastasis by suppression of tumor cell seeding.
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ABSTRACT:
SUBMITTER: Knopfova L
PROVIDER: S-EPMC6711763 | biostudies-literature | 2018 Feb
REPOSITORIES: biostudies-literature
Publications
Transcription factor c-Myb inhibits breast cancer lung metastasis by suppression of tumor cell seeding.
Knopfová L L Biglieri E E Volodko N N Masařík M M Hermanová M M Glaus Garzón J F JF Dúcka M M Kučírková T T Souček K K Šmarda J J Beneš P P Borsig L L
Oncogene 20171030 8
Metastasis accounts for most of cancer-related deaths. Paracrine signaling between tumor cells and the stroma induces changes in the tumor microenvironment required for metastasis. Transcription factor c-Myb was associated with breast cancer (BC) progression but its role in metastasis remains unclear. Here we show that increased c-Myb expression in BC cells inhibits spontaneous lung metastasis through impaired tumor cell extravasation. On contrary, BC cells with increased lung metastatic capacit ...[more]
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