Dataset Information

Lateral femoral cutaneous nerve block with different volumes of Ropivacaine: a randomized trial in healthy volunteers.

ABSTRACT: BACKGROUND:Nerve block of the lateral femoral cutaneous nerve (LFCN) is a predominantly sensory block. It reduces pain following total hip arthroplasty (THA), but the non-responder rate is high. We hypothesized, that an increased volume of ropivacaine, would result in greater coverage of incisions used for THA. METHODS:We conducted a randomized, blinded trial in 20 healthy volunteers. Participants were randomized to receive bilateral LFCN-blocks with 8?mL ropivacaine 0.75% on the left side and 16?mL ropivacaine 0.75% on the right side, or vice versa. Allocation was blinded to both participants and outcome assessors. Before nerve block performance, incision lines for posterior and lateral THA approaches were depicted with invisible ultraviolet-paint, thereby securing sufficient blinding during outcome assessment. The blocked area was mapped using temperature and mechanical discrimination tests. Quadriceps muscle strength was monitored. Primary outcome was coverage of the posterior incision line assessed by temperature discrimination test. RESULTS:We found no difference in coverage of the posterior or lateral incision lines when comparing LFCN-blocks with 8?mL versus 16?mL of ropivacaine. The blocked area was significantly larger in the 16?mL group, assessed by both temperature discrimination test (p?=?0.012) and mechanical discrimination test (p?=?0.034). We observed no difference between groups regarding quadriceps muscle strength (p?=?1.0). CONCLUSIONS:A LFCN-block with increased volume of ropivacaine from 8?mL to 16?mL did not result in a greater coverage of posterior or lateral incision lines used for THA, but in a larger blocked sensory area. TRIAL REGISTRATION:Clinicaltrials.gov: NCT03138668 . Registered 3rd of May 2017.

SUBMITTER: Vilhelmsen F

PROVIDER: S-EPMC6712695 | biostudies-literature | 2019 Aug

REPOSITORIES: biostudies-literature

ACCESS DATA

Publications

Lateral femoral cutaneous nerve block with different volumes of Ropivacaine: a randomized trial in healthy volunteers.

Vilhelmsen Frederik F Nersesjan Mariam M Andersen Jakob Hessel JH Danker Jakob Klim JK Broeng Leif L Hägi-Pedersen Daniel D Mathiesen Ole O Thybo Kasper Højgaard KH

BMC anesthesiology 20190828 1

<h4>Background</h4>Nerve block of the lateral femoral cutaneous nerve (LFCN) is a predominantly sensory block. It reduces pain following total hip arthroplasty (THA), but the non-responder rate is high. We hypothesized, that an increased volume of ropivacaine, would result in greater coverage of incisions used for THA.<h4>Methods</h4>We conducted a randomized, blinded trial in 20 healthy volunteers. Participants were randomized to receive bilateral LFCN-blocks with 8 mL ropivacaine 0.75% on the ...[more]

PMID: 31455249

Similar Datasets

Project description:BACKGROUND:Traumatic injury of the femur resulting in femoral fracture may result in significant postoperative pain. As with other causes of acute pain, regional anesthesia may offer a benefit over conventional therapy with intravenous opioids. This study prospectively assesses the effects of femoral nerve blockade with a lateral femoral cutaneous nerve block (FN-LFCN) on intraoperative anesthetic requirements, postoperative pain scores, and opioid requirements. MATERIALS AND METHODS:Seventeen pediatric patients (age 2-18 years) undergoing surgical repair of a traumatic femur fracture fulfilled the study criteria and were randomly assigned to general anesthesia with either an FN-LFCN block (n = 10) or intravenous opioids (n = 7). All patients received a general anesthetic with isoflurane for maintenance anesthesia during the surgical repair of the femur fracture. Patients randomized to the FN-LFCN block group received ultrasound-guided nerve blockade using ropivacaine (0.2%/0.5% based on patient weight). At the conclusion of surgery, the airway device was removed once tracheal extubation criteria were achieved, and patients were transported to the post-anesthesia care unit (PACU) for recovery and assessment of pain by a blinded study nurse. RESULTS:The final study cohort included 17 patients (n = 10 for FN-LFCN block group; n = 7 for the intravenous opioid group). Although the median of the maximum postoperative pain scores in the regional group was 0, this did not reach statistical significance when compared to the median pain score of 3 in the intravenous opioid group. Likewise, no difference between the two groups was noted when comparing intraoperative anesthetic requirements, opioid requirements (intraoperative, in the post-anesthesia recovery room, and in the inpatient ward), and the time to first opioid requirement postoperatively in the inpatient ward. CONCLUSION:This prospective, randomized, double-blinded study failed to demonstrate a clear benefit of regional anesthesia over intravenous opioids intraoperatively and postoperatively during repair of femoral shaft fractures in the pediatric population.

Dataset Information

Lateral femoral cutaneous nerve block with different volumes of Ropivacaine: a randomized trial in healthy volunteers.

Publications

Lateral femoral cutaneous nerve block with different volumes of Ropivacaine: a randomized trial in healthy volunteers.

Similar Datasets

OmicsDI is part of the ELIXIR infrastructure

Tweets