Ontology highlight
ABSTRACT:
SUBMITTER: Qi J
PROVIDER: S-EPMC6712926 | biostudies-literature | 2019
REPOSITORIES: biostudies-literature
Qi Junpeng J Hymel David D Nelson Christopher G CG Burke Terrence R TR Rader Christoph C
Frontiers in immunology 20190821
T-cell engaging bispecific antibodies (biAbs) can mediate potent and specific tumor cell eradication in liquid cancers. Substantial effort has been invested in expanding this concept to solid cancers. To explore their utility in the treatment of ovarian cancer, we built a set of asymmetric biAbs in IgG1-like format that bind CD3 on T cells with a conventional scFv arm and folate receptor 1 (FOLR1) on ovarian cancer cells with a conventional or a chemically programmed Fab arm. For avidity enginee ...[more]