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ABSTRACT:
SUBMITTER: Ugwuja DI
PROVIDER: S-EPMC6713104 | biostudies-literature | 2019 Dec
REPOSITORIES: biostudies-literature
Journal of enzyme inhibition and medicinal chemistry 20191201 1
Fourteen novel dipeptide carboxamide derivatives bearing benzensulphonamoyl propanamide were synthesized and characterized using <sup>1</sup>H NMR, <sup>13</sup>C NMR, FTIR and MS spectroscopic techniques. <i>In vivo</i> antimalarial and <i>in vitro</i> antimicrobial studies were carried out on these synthesized compounds. Molecular docking, haematological analysis, liver and kidney function tests were also evaluated to assess the effect of the compounds on the organs. At 200 mg/kg body weight, ...[more]