Ontology highlight
ABSTRACT:
SUBMITTER: Sabatier LL
PROVIDER: S-EPMC6713207 | biostudies-literature | 2019 Dec
REPOSITORIES: biostudies-literature
Sabatier Laureano L LL Palestro Pablo H PH Enrique Andrea V AV Pastore Valentina V Sbaraglini María L ML Martín Pedro P Gavernet Luciana L
Journal of enzyme inhibition and medicinal chemistry 20191201 1
In this investigation, we studied a family of compounds with an oxathiazolidine-4-one-2,2-dioxide skeleton and their amide synthetic precursors as new anticonvulsant drugs. The cyclic structures were synthesized using a three-step protocol that include solvent-free reactions and microwave-assisted heating. The compounds were tested <i>in vivo</i> through maximal electroshock seizure test in mice. All the structures showed activity at the lower doses tested (30 mg/Kg) and no signs of neurotoxicit ...[more]