Ontology highlight
ABSTRACT:
SUBMITTER: van Putten R
PROVIDER: S-EPMC6713403 | biostudies-literature | 2019 Aug
REPOSITORIES: biostudies-literature
van Putten Robbert R Filonenko Georgy A GA Gonzalez de Castro Angela A Liu Chong C Weber Manuela M Müller Christian C Lefort Laurent L Pidko Evgeny E
Organometallics 20190815 16
The catalytic asymmetric transfer hydrogenation (ATH) of ketones is a powerful methodology for the practical and efficient installation of chiral centers. Herein, we describe the synthesis, characterization, and catalytic application of a series of manganese complexes bearing simple chiral diamine ligands. We performed an extensive experimental and computational mechanistic study and present the first detailed experimental kinetic study of Mn-catalyzed ATH. We demonstrate that conventional mecha ...[more]