Identification of candidate genes and miRNAs associated with neuropathic pain induced by spared nerve injury.

ABSTRACT: Neuropathic pain (NP) is a complex, chronic pain condition caused by injury or dysfunction affecting the somatosensory nervous system. This study aimed to identify crucial genes and miRNAs involved in NP. Microarray data (access number GSE91396) were downloaded from the Gene Expression Omnibus (GEO). Murine RNA‑seq samples from three brain regions [nucleus accumbens, (NAc); medial prefrontal cortex, (mPFC) and periaqueductal gray, (PAG)]were compared between the spared nerve injury (SNI) model and a sham surgery. After data normalization, differentially expressed RNAs were screened using the limma package and functional enrichment analysis was performed with Database for Annotation, Visualization and Integrated Discovery. The microRNA (miRNA/miR)‑mRNA regulatory network and miRNA‑target ge

SUBMITTER: Li H 

PROVIDER: S-EPMC6713433 | biostudies-literature | 2019 Oct

REPOSITORIES: biostudies-literature