Ontology highlight
ABSTRACT:
SUBMITTER: Irons EE
PROVIDER: S-EPMC6713473 | biostudies-literature | 2019 Aug
REPOSITORIES: biostudies-literature
Irons Eric E EE Lee-Sundlov Melissa M MM Zhu Yuqi Y Neelamegham Sriram S Hoffmeister Karin M KM Lau Joseph Ty JT
eLife 20190813
The immune response relies on the integration of cell-intrinsic processes with cell-extrinsic cues. During infection, B cells vacate the marrow during emergency granulopoiesis but return upon restoration of homeostasis. Here we report a novel glycosylation-mediated crosstalk between marrow B cells and hematopoietic progenitors. Human B cells secrete active ST6GAL1 sialyltransferase that remodels progenitor cell surface glycans to suppress granulopoiesis. In mouse models, ST6GAL1 from B cells alt ...[more]