Ontology highlight
ABSTRACT:
SUBMITTER: Lin X
PROVIDER: S-EPMC6713719 | biostudies-literature | 2019
REPOSITORIES: biostudies-literature
Lin Xiaoyuan X Pavani Krishna Chaitanya KC Smits Katrien K Deforce Dieter D Heindryckx Björn B Van Soom Ann A Peelman Luc L
Frontiers in genetics 20190822
In a previous study, we found miR-10b to be more abundant in a conditioned culture medium of degenerate embryos compared to that of blastocysts. Here, we show that miR-10b mimics added to the culture medium can be taken up by embryos. This uptake results in an increase in embryonic cell apoptosis and aberrant expression of DNA methyltransferases (<i>DNMTs</i>). Using several algorithms, Homeobox A1 (<i>HOXA1</i>) was identified as one of the potential miR-10b target genes and dual-luciferase ass ...[more]