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Nigrostriatal and mesolimbic control of sleep-wake behavior in rat.


ABSTRACT: The midbrain dopamine system via the dorsal and ventral striatum regulates a wide range of behaviors. To dissect the role of dopaminergic projections to the dorsal striatum (nigrostriatal projection) and ventral striatum (mesolimbic projection) in sleep-wake behavior, we selectively chemogenetically stimulated nigrostriatal or mesolimbic projections and examined the resulting effects on sleep in rats. Stimulation of nigrostriatal pathways increased sleep and EEG delta power, while stimulation of mesolimbic pathways decreased sleep and reduced cortical EEG power. These results indicate that midbrain dopamine signaling in the dorsal or ventral striatum promotes sleep or wake, respectively.

SUBMITTER: Qiu MH 

PROVIDER: S-EPMC6713786 | biostudies-literature | 2019 Sep

REPOSITORIES: biostudies-literature

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Nigrostriatal and mesolimbic control of sleep-wake behavior in rat.

Qiu Mei-Hong MH   Zhong Zhi-Gang ZG   Chen Michael C MC   Lu Jun J  

Brain structure & function 20190719 7


The midbrain dopamine system via the dorsal and ventral striatum regulates a wide range of behaviors. To dissect the role of dopaminergic projections to the dorsal striatum (nigrostriatal projection) and ventral striatum (mesolimbic projection) in sleep-wake behavior, we selectively chemogenetically stimulated nigrostriatal or mesolimbic projections and examined the resulting effects on sleep in rats. Stimulation of nigrostriatal pathways increased sleep and EEG delta power, while stimulation of  ...[more]

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