Nigrostriatal and mesolimbic control of sleep-wake behavior in rat.
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ABSTRACT:
SUBMITTER: Qiu MH
PROVIDER: S-EPMC6713786 | biostudies-literature | 2019 Sep
REPOSITORIES: biostudies-literature
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Nigrostriatal and mesolimbic control of sleep-wake behavior in rat.
Qiu Mei-Hong MH Zhong Zhi-Gang ZG Chen Michael C MC Lu Jun J
Brain structure & function 20190719 7
The midbrain dopamine system via the dorsal and ventral striatum regulates a wide range of behaviors. To dissect the role of dopaminergic projections to the dorsal striatum (nigrostriatal projection) and ventral striatum (mesolimbic projection) in sleep-wake behavior, we selectively chemogenetically stimulated nigrostriatal or mesolimbic projections and examined the resulting effects on sleep in rats. Stimulation of nigrostriatal pathways increased sleep and EEG delta power, while stimulation of ...[more]
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