Ontology highlight
ABSTRACT:
SUBMITTER: Tang X
PROVIDER: S-EPMC6713854 | biostudies-literature | 2019 Sep
REPOSITORIES: biostudies-literature
Tang Xin X Zhao Shasha S Zhang Yang Y Wang Yuelong Y Zhang Zongliang Z Yang Meijia M Zhu Yanyu Y Zhang Guanjie G Guo Gang G Tong Aiping A Zhou Liangxue L
Molecular therapy oncolytics 20190723
Glioblastoma (GBM) remains one of the most malignant primary tumors in adults, with a 5-year survival rate less than 10% because of lacking effective treatment. Here, we aimed to explore whether B7-H3 could serve as a novel therapeutic target for GBM in chimeric antigen receptor (CAR) T cell therapy. In this study, a CAR targeting B7-H3 was constructed and transduced into T cells by lentivirus. Antitumor effects of B7-H3-specific CAR-T cells were assessed with primary and GBM cell lines both <i> ...[more]