Ontology highlight
ABSTRACT:
SUBMITTER: Ghaheh HS
PROVIDER: S-EPMC6714118 | biostudies-literature | 2019 Aug
REPOSITORIES: biostudies-literature
Ghaheh Hooria Seyedhosseini HS Ganjalikhany Mohamad Reza MR Yaghmaei Parichehreh P Pourfarzam Morteza M Mir Mohammad Sadeghi Hamid H
Research in pharmaceutical sciences 20190801 4
Reteplase (recombinant plasminogen activator, r-PA) is a thrombolytic agent recombined from tissue-type plasminogen activator (t-PA), which has several prominent features such as strong thrombolytic ability and <i>E. coli</i> expressibility. Despite these outstanding features, it demonstrates reduced fibrin binding affinity, reduced stimulation of protease activity, and lower solubility, hence higher aggregation propensity, compared to t-PA. The present study was devoted to design r-PA variants ...[more]