Ontology highlight
ABSTRACT:
SUBMITTER: van der Helm D
PROVIDER: S-EPMC6714167 | biostudies-literature | 2019 Sep
REPOSITORIES: biostudies-literature
van der Helm Danny D Barnhoorn Marieke C MC de Jonge-Muller Eveline S M ESM Molendijk Ilse I Hawinkels Luuk J A C LJAC Coenraad Minneke J MJ van Hoek Bart B Verspaget Hein W HW
Journal of cellular and molecular medicine 20190627 9
Chronic liver injury leads to the accumulation of myofibroblasts resulting in increased collagen deposition and hepatic fibrogenesis. Treatments specifically targeting fibrogenesis are not yet available. Mesenchymal stromal cells (MSCs) are fibroblast-like stromal (stem) cells, which stimulate tissue regeneration and modulate immune responses. In the present study we assessed whether liver fibrosis and cirrhosis can be reversed by treatment with MSCs or fibroblasts concomitant to partial hepatec ...[more]