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Positive association between baseline brachial-ankle pulse wave velocity and the risk of new-onset diabetes in hypertensive patients.


ABSTRACT: BACKGROUND:There is no clearly defined temporal relationship between arterial stiffness and diabetes. We aimed to investigate the prospective association between baseline brachial-ankle pulse wave velocity (baPWV) and the risk of new-onset diabetes during follow-up, and examined whether there were effect modifiers, in hypertensive patients. METHODS:We included 2429 hypertensive patients with all the pertinent data but without diabetes at the baseline, who were part of the China Stroke Primary Prevention Trial (CSPPT), a randomized, double-blind, actively controlled trial conducted in 32 communities in Anhui and Jiangsu provinces in China. The primary outcome was new-onset diabetes, defined as physician-diagnosed diabetes or use of glucose-lowering drugs during follow-up, or fasting glucose (FG)???126.0 mg/dL at the exit visit. RESULTS:During a median follow-up duration of 4.5 years, 287 (11.8%) participants developed diabetes. There was a significant positive association between baseline baPWV and the risk of new-onset diabetes (per SD increment; OR, 1.33; 95% CI 1.13, 1.56). Consistently, when baPWV was assessed as quartiles, a significantly higher risk of new-onset diabetes was found in participants in quartiles 2-4 (??15.9 m/s; OR, 1.80; 95% CI 1.22, 2.65) compared with those in quartile 1 (

SUBMITTER: Zhang Y 

PROVIDER: S-EPMC6714437 | biostudies-literature | 2019 Aug

REPOSITORIES: biostudies-literature

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Positive association between baseline brachial-ankle pulse wave velocity and the risk of new-onset diabetes in hypertensive patients.

Zhang Yuanyuan Y   He Panpan P   Li Youbao Y   Zhang Yan Y   Li Jianping J   Liang Min M   Wang Guobao G   Tang Genfu G   Song Yun Y   Wang Binyan B   Liu Chengzhang C   Liu Lishun L   Cui Yimin Y   Wang Xiaobin X   Huo Yong Y   Xu Xiping X   Qin Xianhui X  

Cardiovascular diabetology 20190828 1


<h4>Background</h4>There is no clearly defined temporal relationship between arterial stiffness and diabetes. We aimed to investigate the prospective association between baseline brachial-ankle pulse wave velocity (baPWV) and the risk of new-onset diabetes during follow-up, and examined whether there were effect modifiers, in hypertensive patients.<h4>Methods</h4>We included 2429 hypertensive patients with all the pertinent data but without diabetes at the baseline, who were part of the China St  ...[more]

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