Dataset Information

Investigating the Acid Site Distribution of a New-Generation Methyl Chloride Synthesis Catalyst.

ABSTRACT: The effect of modifying an ?-alumina methyl chloride synthesis catalyst by doping with CsCl and KCl over the concentration range of 0.1-1.0 mmol g(cat) -1 is investigated by a combination of pyridine chemisorption coupled with infrared spectroscopy and mass-selective temperature-programmed desorption measurements. The loading of group 1 metal chloride is equivalent to a titrant that enables selective neutralization of Lewis acid sites present at the surface of the reference ?-alumina catalyst. Specifically, a loading of 0.1 mmol g(cat) -1 is sufficient to neutralize the strong Lewis acid sites; a loading of 0.6 mmol g(cat) -1 is sufficient to neutralize the strong and medium-strong Lewis acid sites; a loading of 1.0 mmol g(cat) -1 neutralizes all of the strong and medium-strong Lewis acid sites and partially neutralizes the medium-weak Lewis acid site. These deductions connect with a catalyst design program to develop a methyl chloride synthesis catalyst that exhibits minimal formation of the byproduct dimethyl ether.

SUBMITTER: McInroy AR

PROVIDER: S-EPMC6714609 | biostudies-literature | 2019 Aug

REPOSITORIES: biostudies-literature

ACCESS DATA

Publications

Investigating the Acid Site Distribution of a New-Generation Methyl Chloride Synthesis Catalyst.

McInroy Alastair R AR Winfield John M JM Dudman Christopher C CC Jones Peter P Lennon David D

ACS omega 20190812 9

The effect of modifying an η-alumina methyl chloride synthesis catalyst by doping with CsCl and KCl over the concentration range of 0.1-1.0 mmol g<sub>(cat)</sub> <sup>-1</sup> is investigated by a combination of pyridine chemisorption coupled with infrared spectroscopy and mass-selective temperature-programmed desorption measurements. The loading of group 1 metal chloride is equivalent to a titrant that enables selective neutralization of Lewis acid sites present at the surface of the reference ...[more]

PMID: 31497716

Similar Datasets

Project description:For a long time nucleic acid-based approaches directed towards controlling the propagation of Hepatitis C Virus (HCV) have been considered to possess high potential. Towards this end, ribozymes (i.e. RNA enzymes) that specifically recognize and subsequently catalyze the cleavage of their RNA substrate present an attractive molecular tool. Here, the unique properties of a new generation of ribozymes are taken advantage of in order to develop an efficient and durable ribozyme-based technology with which to target HCV (+) RNA strands. These ribozymes resulted from the coupling of a specific on/off adaptor (SOFA) to the ribozyme domain derived from the Hepatitis Delta Virus (HDV). The former switches cleavage activity "on" solely in the presence of the desired RNA substrate, while the latter was the first catalytic RNA reported to function naturally in human cells, specifically in hepatocytes. In order to maximize the chances for success, a step-by-step approach was used for both the design and the selection of the ribozymes. This approach included the use of both bioinformatics and biochemical methods for the identification of the sites possessing the greatest potential for targeting, and the subsequent in vitro testing of the cleavage activities of the corresponding SOFA-HDV ribozymes. These efforts led to a significant improvement in the ribozymes' designs. The ability of the resulting SOFA-HDV ribozymes to inhibit HCV replication was further examined using a luciferase-based replicon. Although some of the ribozymes exhibited high levels of cleavage activity in vitro, none appears to be a potential long term inhibitor in cellulo. Analysis of recent discoveries in the cellular biology of HCV might explain this failure, as well as provide some ideas on the potential limits of using nucleic acid-based drugs to control the propagation of HCV. Finally, the above conclusions received support from experiments performed using a collection of SOFA-HDV ribozymes directed against HCV (-) strands.

Dataset Information

Investigating the Acid Site Distribution of a New-Generation Methyl Chloride Synthesis Catalyst.

Publications

Investigating the Acid Site Distribution of a New-Generation Methyl Chloride Synthesis Catalyst.

Similar Datasets

OmicsDI is part of the ELIXIR infrastructure

Tweets