Ontology highlight
ABSTRACT:
SUBMITTER: Song M
PROVIDER: S-EPMC6715294 | biostudies-literature | 2018 Jul
REPOSITORIES: biostudies-literature
Song Mengqiu M Liu Xuejiao X Liu Kangdong K Zhao Ran R Huang Hai H Shi Yuanyuan Y Zhang Man M Zhou Silei S Xie Hua H Chen Hanyong H Li Yin Y Zheng Yan Y Wu Qiong Q Liu Fangfang F Li Enmin E Bode Ann M AM Dong Zigang Z Lee Mee-Hyun MH
Molecular cancer therapeutics 20180425 7
Overexpression or activation of AKT is very well known to control cell growth, survival, and gene expression in solid tumors. Oridonin, an inflammatory medical and diterpenoid compound isolated from <i>Rabdosia rubescens</i>, has exhibited various pharmacologic and physiologic properties, including antitumor, antibacterial, and anti-inflammatory effects. In this study, we demonstrated that oridonin is an inhibitor of AKT and suppresses proliferation of esophageal squamous cell carcinoma (ESCC) < ...[more]