Ontology highlight
ABSTRACT:
SUBMITTER: Tomassoni-Ardori F
PROVIDER: S-EPMC6715404 | biostudies-literature | 2019 Aug
REPOSITORIES: biostudies-literature
Tomassoni-Ardori Francesco F Fulgenzi Gianluca G Becker Jodi J Barrick Colleen C Palko Mary Ellen ME Kuhn Skyler S Koparde Vishal V Cam Maggie M Yanpallewar Sudhirkumar S Oberdoerffer Shalini S Tessarollo Lino L
eLife 20190820
Brain-derived neurotrophic factor (BDNF) is a potent modulator of brain synaptic plasticity. Signaling defects caused by dysregulation of its Ntrk2 (TrkB) kinase (TrkB.FL) and truncated receptors (TrkB.T1) have been linked to the pathophysiology of several neurological and neurodegenerative disorders. We found that upregulation of Rbfox1, an RNA binding protein associated with intellectual disability, epilepsy and autism, increases selectively hippocampal TrkB.T1 isoform expression. Physiologica ...[more]