Carcinogenic risk of human papillomavirus (HPV) genotypes and potential effects of HPV vaccines in Korea.

ABSTRACT: This study investigated the distribution of HPV types in Korean women and evaluated the carcinogenic risk of individual HPV types and the potential effects of HPV vaccines. A total of 4,081 HPV-positive samples between 2014 and 2017 were included. The most prevalent genotypes were HPV 16, 58, 68, and 56. Among them, HPV 16 was significantly higher in high-grade squamous intraepithelial neoplasia or worse (HSIL+?) group. In cytologically evaluating the risk for HSIL+ by individual HPV types, HPV 16 was associated with the highest risk of HSIL+ (OR?=?10.82; 95% CI: 7.93-14.77), followed by HPV 33, 31, 52, 18, 58, 51, and 35, in descending order (OR?=?3.50 [type 33] to 2.62 [type 35]). Among those types, HPV 16, 18, 31, 33, and 58 were also significantly associated with HSIL+ on histologic evaluation. The analysis of the HPV subgroups covered by the different vaccines revealed that the HPV types covered by the 9-valent vaccine had a high association with HSIL+ (OR?=?4.09; 95% CI: 3.02-5.54). Our findings highlight the different carcinogenic risks posed by the high risk HPV genotypes and the positive potential effects of the 9-valent HPV vaccine in reducing HPV-associated cervical cancer in Korea.

SUBMITTER: Park E 

PROVIDER: S-EPMC6715722 | biostudies-literature | 2019 Aug

REPOSITORIES: biostudies-literature