Ontology highlight
ABSTRACT:
SUBMITTER: Li R
PROVIDER: S-EPMC6715734 | biostudies-literature | 2019 Aug
REPOSITORIES: biostudies-literature
Li Ran R Bitoun Emmanuelle E Altemose Nicolas N Davies Robert W RW Davies Benjamin B Myers Simon R SR
Nature communications 20190829 1
During meiotic recombination, homologue-templated repair of programmed DNA double-strand breaks (DSBs) produces relatively few crossovers and many difficult-to-detect non-crossovers. By intercrossing two diverged mouse subspecies over five generations and deep-sequencing 119 offspring, we detect thousands of crossover and non-crossover events genome-wide with unprecedented power and spatial resolution. We find that both crossovers and non-crossovers are strongly depleted at DSB hotspots where th ...[more]