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Synthesis of controlled, high-molecular weight poly(l-glutamic acid) brush polymers.

ABSTRACT: We report the synthesis and characterization of high-molecular weight poly(l-glutamic acid) based brush polymers. Utilizing a combination of ring-opening metathesis polymerization of norbornene based monomers and ring-opening polymerization of ?-benzyl-l-glutamate N-carboxyanhydride, high-molecular weight ?-benzyl protected poly(l-glutamic acid) brush polymers are synthesized. Controlled and complete deprotection of the benzyl groups using trimethylsilyl iodide resulted in poly(l-glutamic acid) based brush polymers with molecular weights up to 3.6 MDa, which may potentially be used to prepare size-controlled unimolecular polymeric nanomedicine for drug delivery applications. Camptothecin brush poly(l-glutamic acid) conjugates were prepared and their stability, drug release kinetics, and in vitro toxicity were studied.

SUBMITTER: Baumgartner R

PROVIDER: S-EPMC6716790 | biostudies-literature | 2017 Aug

REPOSITORIES: biostudies-literature

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Synthesis of controlled, high-molecular weight poly(l-glutamic acid) brush polymers.

Baumgartner Ryan R Kuai Diane D Cheng Jianjun J

Biomaterials science 20170801 9

We report the synthesis and characterization of high-molecular weight poly(l-glutamic acid) based brush polymers. Utilizing a combination of ring-opening metathesis polymerization of norbornene based monomers and ring-opening polymerization of γ-benzyl-l-glutamate N-carboxyanhydride, high-molecular weight γ-benzyl protected poly(l-glutamic acid) brush polymers are synthesized. Controlled and complete deprotection of the benzyl groups using trimethylsilyl iodide resulted in poly(l-glutamic acid) ...[more]

PMID: 28664205

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