Ontology highlight
ABSTRACT:
SUBMITTER: Welch JD
PROVIDER: S-EPMC6716797 | biostudies-literature | 2019 Jun
REPOSITORIES: biostudies-literature
Welch Joshua D JD Kozareva Velina V Ferreira Ashley A Vanderburg Charles C Martin Carly C Macosko Evan Z EZ
Cell 20190606 7
Defining cell types requires integrating diverse single-cell measurements from multiple experiments and biological contexts. To flexibly model single-cell datasets, we developed LIGER, an algorithm that delineates shared and dataset-specific features of cell identity. We applied it to four diverse and challenging analyses of human and mouse brain cells. First, we defined region-specific and sexually dimorphic gene expression in the mouse bed nucleus of the stria terminalis. Second, we analyzed e ...[more]