Ontology highlight
ABSTRACT:
SUBMITTER: Shah KK
PROVIDER: S-EPMC6717027 | biostudies-literature | 2019 Sep
REPOSITORIES: biostudies-literature
Shah Kushani K KK Whitaker Robert H RH Busby Theodore T Hu Jing J Shi Bi B Wang Zhenjia Z Zang Chongzhi C Placzek William J WJ Jiang Hao H
Experimental cell research 20190626 2
DPY30 facilitates H3K4 methylation by directly binding to ASH2L in the SET1/MLL complexes and plays an important role in hematologic malignancies. However, the domain on DPY30 that regulates cancer growth is not evident, and the potential of pharmacologically targeting this chromatin modulator to inhibit cancer has not been explored. Here we have developed a peptide-based strategy to specifically target DPY30 activity. We have designed cell-penetrating peptides derived from ASH2L that can either ...[more]