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Genetic variants in the WNT signaling pathway are protectively associated with colorectal cancer in a Saudi population.

ABSTRACT: The Wnt/?-catenin signaling pathway has been etiologically implicated in the development and progression of colorectal cancer. We studied thirteen single nucleotide polymorphisms (SNPs) located in SFRP3 (rs7775), CTNNB1 (?-catenin) [rs4135385, rs13072632], APC (rs454886, rs459552), LRP6 (rs2075241, rs2284396), DKK4 (rs3763511), DKK3 (rs6485350), TCF4 (rs12255372) and AXIN2 (rs3923086, rs3923087, rs4791171) in patients with colorectal cancer (n?=?122) and controls (n?=?110). Evaluation of WNT pathway SNPs showed protective association for rs4135385, located in ?-catenin. Additionally, variants in SFRP3 (rs7775) and LRP6 (rs2284396) which did not show any association in the overall analysis were significantly associated with female and old aged colorectal cancer patients, respectively.

SUBMITTER: Parine NR

PROVIDER: S-EPMC6717108 | biostudies-literature | 2019 Feb

REPOSITORIES: biostudies-literature

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Genetic variants in the WNT signaling pathway are protectively associated with colorectal cancer in a Saudi population.

Parine Narasimha Reddy NR Azzam Nahla A NA Shaik Jilani J Aljebreen Abdulrahman M AM Alharbi Othman O Almadi Majid A MA Alanazi Mohammad M Khan Zahid Z

Saudi journal of biological sciences 20180517 2

The Wnt/β-catenin signaling pathway has been etiologically implicated in the development and progression of colorectal cancer. We studied thirteen single nucleotide polymorphisms (SNPs) located in SFRP3 (rs7775), CTNNB1 (β-catenin) [rs4135385, rs13072632], APC (rs454886, rs459552), LRP6 (rs2075241, rs2284396), DKK4 (rs3763511), DKK3 (rs6485350), TCF4 (rs12255372) and AXIN2 (rs3923086, rs3923087, rs4791171) in patients with colorectal cancer (n = 122) and controls (n = 110). Evaluation of WNT pat ...[more]

PMID: 31485167

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