Ontology highlight
ABSTRACT:
SUBMITTER: Ferre G
PROVIDER: S-EPMC6717258 | biostudies-literature | 2019 Aug
REPOSITORIES: biostudies-literature
Ferré Guillaume G Louet Maxime M Saurel Oliver O Delort Bartholomé B Czaplicki Georges G M'Kadmi Céline C Damian Marjorie M Renault Pedro P Cantel Sonia S Gavara Laurent L Demange Pascal P Marie Jacky J Fehrentz Jean-Alain JA Floquet Nicolas N Milon Alain A Banères Jean-Louis JL
Proceedings of the National Academy of Sciences of the United States of America 20190815 35
Ghrelin plays a central role in controlling major biological processes. As for other G protein-coupled receptor (GPCR) peptide agonists, the structure and dynamics of ghrelin bound to its receptor remain obscure. Using a combination of solution-state NMR and molecular modeling, we demonstrate that binding to the growth hormone secretagogue receptor is accompanied by a conformational change in ghrelin that structures its central region, involving the formation of a well-defined hydrophobic core. ...[more]