Toxoplasma gondii effector TgIST blocks type I interferon signaling to promote infection.
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ABSTRACT:
SUBMITTER: Matta SK
PROVIDER: S-EPMC6717281 | biostudies-literature | 2019 Aug
REPOSITORIES: biostudies-literature
Publications
<i>Toxoplasma gondii</i> effector TgIST blocks type I interferon signaling to promote infection.
Matta Sumit K SK Olias Philipp P Huang Zhou Z Wang Qiuling Q Park Eugene E Yokoyama Wayne M WM Sibley L David LD
Proceedings of the National Academy of Sciences of the United States of America 20190814 35
In contrast to the importance of type II interferon-γ (IFN-γ) in control of toxoplasmosis, the role of type I IFN is less clear. We demonstrate here that TgIST, a secreted effector previously implicated in blocking type II IFN-γ signaling, also blocked IFN-β responses by inhibiting STAT1/STAT2-mediated transcription in infected cells. Consistent with a role for type I IFN in cell intrinsic control, ∆<i>Tgis</i>t mutants were more susceptible to growth inhibition by murine and human macrophages a ...[more]
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