Ontology highlight
ABSTRACT:
SUBMITTER: Biterova EI
PROVIDER: S-EPMC6717300 | biostudies-literature | 2019 Aug
REPOSITORIES: biostudies-literature
Biterova Ekaterina I EI Isupov Michail N MN Keegan Ronan M RM Lebedev Andrey A AA Sohail Anil A AA Liaqat Inam I Alanen Heli I HI Ruddock Lloyd W LW
Proceedings of the National Academy of Sciences of the United States of America 20190808 35
Microsomal triglyceride transfer protein (MTP) plays an essential role in lipid metabolism, especially in the biogenesis of very low-density lipoproteins and chylomicrons via the transfer of neutral lipids and the assembly of apoB-containing lipoproteins. Our understanding of the molecular mechanisms of MTP has been hindered by a lack of structural information of this heterodimeric complex comprising an MTPα subunit and a protein disulfide isomerase (PDI) β-subunit. The structure of MTP presente ...[more]