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Associations between the phenotype and genotype of MnSOD and catalase in periodontal disease.

ABSTRACT: BACKGROUND:Periodontal disease is an inflammatory disease in which pathogenic infections trigger a series of inflammatory responses and redox regulation. The hypothesis of this study was that a host's redox regulation, as modified by genetic polymorphisms, may affect periodontal disease activities (including the plaque index (PlI), bleeding on probing (BOP), and pocket depth (PD)) during periodontal therapy. METHODS:In total, 175 patients diagnosed with periodontitis were recruited from the Department of Periodontology, Taipei Medical University Hospital. Both saliva samples and clinical measurements (PlI, BOP, and PD) were taken at the baseline and at 1?month after completing treatment. Salivary manganese superoxide dismutase (MnSOD) and catalase, and corresponding genetic polymorphisms (MnSOD, T47C, rs4880 and Catalase, C-262?T, rs1001179) were determined. The extent of change (?) of MnSOD or catalase was calculated by subtracting the concentration after completing treatment from that at the baseline. RESULTS:Subjects who carried the Catalase CC genotype had significantly higher salivary MnSOD or catalase levels. The MnSOD genotype had a significant effect on the percentage of PDs of 4~9?mm (p =?0.02), and salivary ?MnSOD had a significant effect on the PlI (p =?0.03). The Catalase genotype had a significant effect on the PlI (p =?0.01~0.04), but the effect was not found for the mean PlI or PD. There was a significant interaction between the MnSOD genotype and salivary ?MnSOD on PDs of 4~9?mm. After adjusting for gender, years of schooling, smoking status, and alcohol consumption, subjects with ?MnSOD of

SUBMITTER: Lee CY

PROVIDER: S-EPMC6717336 | biostudies-literature | 2019 Aug

REPOSITORIES: biostudies-literature

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Associations between the phenotype and genotype of MnSOD and catalase in periodontal disease.

Lee Chang-Yu CY Chang Chia-Huang CH Teng Nai-Chia NC Chang Hung-Ming HM Huang Wan-Ting WT Huang Yung-Kai YK

BMC oral health 20190830 1

<h4>Background</h4>Periodontal disease is an inflammatory disease in which pathogenic infections trigger a series of inflammatory responses and redox regulation. The hypothesis of this study was that a host's redox regulation, as modified by genetic polymorphisms, may affect periodontal disease activities (including the plaque index (PlI), bleeding on probing (BOP), and pocket depth (PD)) during periodontal therapy.<h4>Methods</h4>In total, 175 patients diagnosed with periodontitis were recruite ...[more]

PMID: 31470840

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Associations between the phenotype and genotype of MnSOD and catalase in periodontal disease.

Publications

Associations between the phenotype and genotype of MnSOD and catalase in periodontal disease.

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