Isolation, pharmacological evaluation and molecular docking studies of bioactive compounds from Grewia optiva.

ABSTRACT:

Background

Traditionally, Grewia optiva is widely used for the treatment of many diseases like dysentery, fever, typhoid, diarrhea, eczema, smallpox, malaria and cough.

Methods

Shade-dried roots of G. optiva were extracted with methanol. Based on HPLC results, chloroform and ethyl acetate fractions were subjected to silica column isolation and four compounds: glutaric acid (V), 3,5 dihydroxy phenyl acrylic acid (VI), (2,5 dihydroxy phenyl) 3',6',8'-trihydroxyl-4H chromen-4'-one (VII) and hexanedioic acid (VIII) were isolated in pure form. Ellman's assay was used to determine the anticholinesterase potential of isolated compounds while their antioxidant potential was estimated by DPPH and ABTS scavenging assays.

Results

Amongst

SUBMITTER: Ul Bari W 

PROVIDER: S-EPMC6717395 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature