Facile synthesis of boronic acid-functionalized magnetic nanoparticles for efficient dopamine extraction.

ABSTRACT: Because dopamine (DA) is one of the most critical neurotransmitters that influence a wide variety of motivated human behaviors, it is necessary to develop a facile diagnostic tool that can quantify the physiological level. In this study, core-shell magnetic silica nanoparticles (Fe₃O₄@SiO₂) were prepared using a modified sol-gel reaction. The Fe₃O₄@SiO₂ were functionalized using 3-aminophenylboronic acid (APBA) via a facile and rapid synthetic route, hereafter referred to as Fe₃O₄@SiO₂@APBA The resultant Fe₃O₄@SiO₂@APBA not only adsorbed DA molecules, but also were easily separated from solution using a simple magnetic manipulation. The adsorbed amounts of DA by the Fe₃O₄@SiO₂@APBA were quantified by measuring the changes in fluorescence intensity of polydopamine (at 463 nm) originated from the self-polymerized DA remained in the supernatant before and after the adsorption process. The Fe₃O₄@SiO₂@APBA exhibited two-stage adsorption behavior for DA, and the maximal adsorption capacity was 108.46 ?g/g at pH 8.5. Our particle system demonstrated the potential application for extracting compounds with cis-diols (including catechol amines) from the biological fluid.

SUBMITTER: Kook JK 

PROVIDER: S-EPMC6717740 | biostudies-literature | 2019 Sep

REPOSITORIES: biostudies-literature