Ontology highlight
ABSTRACT:
SUBMITTER: Kloetgen A
PROVIDER: S-EPMC6718347 | biostudies-literature | 2019 Sep
REPOSITORIES: biostudies-literature
Kloetgen Andreas A Thandapani Palaniraja P Tsirigos Aristotelis A Aifantis Iannis I
Trends in immunology 20190815 9
Epigenetic dysregulation plays a profound role in the pathogenesis of hematological malignancies, which is often the result of somatic mutations of chromatin regulators. Previously, these mutations were largely considered to alter gene expression in two dimensions, by activating or repressing chromatin states; however, research in the last decade has highlighted the increasing impact of the 3D organization of the genome in gene regulation and disease pathogenesis. Here, we summarize the current ...[more]